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Benjamin F Cravatt Selected Research

Hydrolases

12/2021Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function.
1/2020Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells.
10/2018The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary Brain Phosphatidylinositol Lipase.
2/2018Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.
1/2017Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.
10/2016An in vivo multiplexed small-molecule screening platform.
1/2016A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation.
7/2015Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases.
7/2015Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.
4/2015Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival.
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Benjamin F Cravatt Research Topics

Disease

50Neoplasms (Cancer)
10/2022 - 08/2002
31Pain (Aches)
06/2018 - 12/2002
18Inflammation (Inflammations)
01/2021 - 04/2004
14Hyperalgesia
01/2018 - 06/2004
11Neuralgia (Stump Neuralgia)
01/2018 - 10/2004
10Neuroinflammatory Diseases
12/2021 - 08/2010
10Breast Neoplasms (Breast Cancer)
06/2016 - 08/2002
9Obesity
12/2019 - 11/2004
7Alzheimer Disease (Alzheimer's Disease)
10/2021 - 07/2011
7Neurodegenerative Diseases (Neurodegenerative Disease)
10/2021 - 11/2011
7Hypothermia
08/2015 - 07/2002
7Catalepsy
08/2015 - 02/2007
6Prostatic Neoplasms (Prostate Cancer)
01/2021 - 04/2011
6Multiple Sclerosis
01/2019 - 08/2011
5Substance-Related Disorders (Drug Abuse)
10/2019 - 06/2002
5Nausea
04/2016 - 04/2012
4Neurocognitive Disorders (Clerambault Syndrome)
01/2022 - 10/2018
4Infections
01/2021 - 05/2009
4Nervous System Diseases (Neurological Disorders)
01/2020 - 02/2011
4Insulin Resistance
01/2020 - 11/2010
4Body Weight (Weight, Body)
03/2016 - 05/2005
4Edema (Dropsy)
03/2013 - 06/2004
3Glioblastoma (Glioblastoma Multiforme)
11/2021 - 11/2016
3Melanoma (Melanoma, Malignant)
11/2020 - 08/2002
3Hearing Loss (Hearing Impairment)
01/2020 - 01/2013
3Polyneuropathies (Polyneuropathy)
01/2020 - 01/2013
3Cataract (Cataracts)
01/2020 - 01/2013
3Atherosclerosis
02/2019 - 01/2011
3Chronic Pain
11/2016 - 12/2010
3Pancreatic Neoplasms (Pancreatic Cancer)
10/2016 - 02/2010
3Ataxia (Dyssynergia)
12/2013 - 07/2007
3Pathologic Processes
12/2007 - 04/2004
3Neoplasm Metastasis (Metastasis)
06/2006 - 09/2004
2Tuberculosis (Tuberculoses)
01/2022 - 03/2012
2Hypertension (High Blood Pressure)
01/2022 - 11/2010
2Brain Neoplasms (Brain Tumor)
11/2021 - 11/2016

Drug/Important Bio-Agent (IBA)

57EnzymesIBA
12/2021 - 08/2002
43EndocannabinoidsIBA
01/2022 - 12/2002
26HydrolasesIBA
12/2021 - 08/2002
25fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA
09/2021 - 04/2004
24anandamide (arachidonylethanolamide)IBA
09/2021 - 12/2002
24Proteins (Proteins, Gene)FDA Link
01/2021 - 12/2003
22CannabinoidsIBA
12/2021 - 06/2002
21Serine (L-Serine)FDA Link
12/2021 - 08/2002
20LipidsIBA
12/2021 - 12/2002
19Pharmaceutical PreparationsIBA
11/2021 - 06/2002
19Monoacylglycerol LipasesIBA
10/2021 - 01/2010
17Cannabinoid Receptors (Cannabinoid Receptor)IBA
01/2021 - 06/2004
9Lipase (Acid Lipase)FDA Link
10/2021 - 01/2013
9JZL 184IBA
01/2018 - 09/2011
8Fatty Acids (Saturated Fatty Acids)IBA
01/2021 - 12/2002
8MJN110IBA
01/2019 - 09/2013
8CB1 Cannabinoid Receptor (CB1 Receptor)IBA
10/2018 - 11/2003
6ProteomeIBA
03/2021 - 08/2002
6Peptide Hydrolases (Proteases)FDA Link
01/2020 - 08/2002
6Cannabinoid Receptor AgonistsIBA
06/2018 - 04/2004
6PF 3845IBA
10/2015 - 04/2009
6Dronabinol (THC)FDA LinkGeneric
08/2015 - 01/2008
6AmidesIBA
01/2014 - 12/2002
5glyceryl 2-arachidonate (2-arachidonoylglycerol)IBA
12/2021 - 08/2010
5CytokinesIBA
01/2021 - 07/2008
5EstersIBA
01/2021 - 04/2010
5Glycerol (Glycerine)FDA LinkGeneric
01/2019 - 04/2012
5Analgesics (Analgesic Drugs)IBA
06/2018 - 11/2007
5CarrageenanIBA
01/2017 - 06/2004
5RimonabantIBA
10/2015 - 07/2002
5Serine Proteases (Serine Protease)IBA
09/2009 - 08/2002
4Phosphotransferases (Kinase)IBA
10/2022 - 10/2012
4Cysteine (L-Cysteine)FDA Link
03/2021 - 06/2016
4Glucose (Dextrose)FDA LinkGeneric
01/2020 - 11/2004
4Morphine (MS Contin)FDA LinkGeneric
06/2018 - 10/2011
4Glutamic Acid (Glutamate)FDA Link
01/2018 - 12/2003
4ProstaglandinsIBA
10/2017 - 11/2011
4Opioid Analgesics (Opioids)IBA
01/2017 - 10/2011
4cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester (URB597)IBA
10/2015 - 05/2007
4Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
06/2006 - 08/2002
3EicosanoidsIBA
10/2021 - 04/2013
3Biological ProductsIBA
01/2021 - 08/2002
3Triglycerides (Triacylglycerol)IBA
01/2021 - 03/2016
3LigandsIBA
01/2021 - 04/2008
3Dimethyl FumarateIBA
01/2019 - 01/2016
3Amyloid (Amyloid Fibrils)IBA
11/2018 - 06/2012
3N-nitroso-N-methyltyramine (NNMT)IBA
01/2018 - 05/2013
3LipopolysaccharidesIBA
12/2017 - 07/2010
3Platelet Activating FactorIBA
07/2015 - 10/2006
3Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
09/2014 - 04/2009
3Diclofenac (SR 38)FDA LinkGeneric
09/2014 - 01/2008
3Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
09/2014 - 01/2008
3Freund's AdjuvantIBA
07/2011 - 03/2009
3Ether (Diethyl Ether)IBA
04/2011 - 10/2006
3Ethanolamine (Colamine)IBA
05/2009 - 06/2004
2Anti-Bacterial Agents (Antibiotics)IBA
01/2022 - 01/2019
2Lipoprotein Lipase (Diacylglycerol Lipase)IBA
12/2021 - 12/2017
2Oncogene Proteins (Oncogene Protein)IBA
11/2021 - 11/2011
2DiglyceridesIBA
10/2021 - 09/2012
2Phospholipases (Phospholipase)IBA
10/2021 - 10/2018

Therapy/Procedure

13Therapeutics
01/2021 - 02/2012
7Analgesia
07/2010 - 11/2004
4Drug Therapy (Chemotherapy)
01/2021 - 10/2011
3Oral Administration
07/2011 - 04/2004